Saturday, June 2, 2012

Everest Sherpas swap danger for luxury watchmaking

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Clinton says Mubarak's fate up to Egyptian people

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Rewriting DNA to understand what it says

Thursday, May 31, 2012

Our ability to "read" DNA has made tremendous progress in the past few decades, but the ability to understand and alter the genetic code, that is, to "rewrite" the DNA-encoded instructions, has lagged behind. A new Weizmann Institute study advances our understanding of the genetic code: It proposes a way of effectively introducing numerous carefully planned DNA segments into genomes of living cells and of testing the effects of these changes. The study is being reported in the June issues of Nature Biotechnology and Nature Genetics.

Until now, changing the DNA sequence has been a slow and labor-intensive process. It took several weeks to alter just one DNA region at a time; testing the effects of each of these changes took even longer. In the new study, Weizmann Institute scientists have developed a technology that makes it possible to simultaneously introduce tens of thousands of DNA regions into tens of thousands of living cells ? each region in a separate cell ? in a planned and systematic manner, and to measure the results of each such change with great precision and within a single experiment.

"This fast method will significantly advance our ability to understand the 'language' of DNA," says research team leader Prof. Eran Segal, of the Weizmann Institute's Computer Science and Applied Mathematics and Molecular Cell Biology Departments. "Reading out a person's entire genome is already a manageable task, but what exactly is written in that genome? After all, a genome looks like a lengthy string of letters whose meaning is for the most part obscure. Just deciphering the DNA letters is like trying to understand a foreign language by listening to it being spoken. Our method will help us identify DNA 'words' and understand their meaning."

Understanding what's written in the DNA might help us interpret, among other things, how genotypic differences among people generate observable differences among them, from the way we look to the way our cells function. Thus, for example, it might be possible to clarify which genetic differences are responsible for the development of various diseases in certain individuals. The Weizmann Institute technology can also lead to improved genetic therapies based on introducing new genes or improved regulatory sequences into cells in order to repair genetic defects.

In the present study, the scientists investigated a vital aspect of the DNA language: How the control of gene expression is encoded in the DNA ? that is, the instructions determining the level of activity of each gene in the genetic code. Since gene activity levels have crucial effects on cell function, this question, considered one of the central in molecular biology, has been studied for decades. The new technology has enabled the scientists to isolate and test the effects of various parameters on gene activity levels: For example, how a gene's activity level is affected by the gene's distance from its regulatory sequence. The researchers have managed to elucidate how various parameters define the regulatory "language" and to demonstrate how deliberate changes in the genetic sequence affect these parameters in a way that alters the level of a gene's activity in a predictable manner.

The new method consists of four steps that combine existing technologies in an innovative manner. The steps are: creation of 50,000 different genetic sequences on DNA chips; massive insertion of these sequences into cells at the same time; sorting the cells with the help of a sorting machine that senses the expression levels of a "reporter" gene; and high-throughput parallel DNA sequencing.

Taking part in the study were Weizmann Institute's graduate students Eilon Sharon, Tali Raveh-Sadka and Michal Levo, research assistant Dr. Yael Kalma and research associate Dr. Adina Weinberger, as well as Dr. Zohar Yakhini from the Technion ? Israel Institute of Technology and Agilent Laboratories, Santa Clara, California.

###

Weizmann Institute of Science: http://www.weizmann.ac.il

Thanks to Weizmann Institute of Science for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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April Rudin: Wealth Gets a Facelift -- How to Attract and Engage New Young Wealthy Clients

While I think it's true that "the rich are getting richer," it's important to note a newer, more quantifiable trend: the rich are getting younger. Heretofore, most wealth creation and/or wealth inheritance events occurred much later in life. One of the major drivers behind creating the new young wealth has been technology. Also in the past, wealthy people tended to transfer wealth upon their death while today an increasing amount of wealth is transferred during life. This leads me to say that wealth is having a "facelift" -- Gen-X and Gen-Y will soon overtake baby-boomers as the wealthiest generation in history. In addition to looking younger, there are many differences in behavior, expectations and values. High net-worth youth will drive increasing demands for mobile information and connectivity and community. Can slow moving industries, like financial services, adjust quickly to the need to retool themselves to meet the "service requirements" and client experience expectations of the first generation to grow up with computers?

Baby-boomers, currently the wealthiest generation, are aging and transferring trillions of dollars of wealth per year. Baby-boomers who are in their late 50s/early 60s now are retiring and changing from "net spenders" to "net savers." Gen-X (born late 1960s-1070s) and Gen-Y (born 1980s-1995) are expected to overtake baby boomers by 2018 in wealth according to a 2008 Wealth Management study by Deloitte. Furthermore, IPO millionaires and the tech world have created an explosion of wealth at a much younger age than ever before. Up to 98 percent of new wealth inheritors (and 70 percent of widows) change advisors! Is this a problem or an opportunity? How can wealth managers and others who provide services to this community quickly change their outlook, messaging and communication style to meet the values which are important to these two generations?

According to one study, the Deloitte Wealth Management "A New Breed. Opportunities for Wealth Managers to Connect with Gen-X and Gen-Y -- 2008," there were 80 million baby-boomers in 2004 worth an estimated $59 trillion. That number is estimated to drop to $46 million by 2018 and continue to trend downwards. Gen-X (estimated 45 million) and Gen-Y (estimated 60 million) were worth $10 trillion in 2004 and their combined wealth is predicted to be at least $28 trillion in 2018. I believe that it's an underestimate due to the IPOs, etc., which were post-2008, but the trending upwards here is the point. What can you do to hold onto existing clients and prepare for the new, wealthy client of the future?

Here are a few of the essentials:

First, your messages must change to match the value propositions that are important to each generation. Baby-boomers (and especially new wealth inheritors) appreciate and value traits such as trust and loyalty. For Gen-X/Gen-Y, those value propositions are unimportant, and, worse yet, can be turn-offs to younger generations looking at your website or reading your materials. Instead, this new generation values transparency and community. They are socially responsible. What messages does your firm promulgate? Do those messages resonate with Gen-X and Gen-Y? Most importantly, does your online presence reflect the same value propositions? If not, you need to give yourself/and your firm and online facelift.

The "facelift" involves changing the style, method and tone with which you present yourself and your firm online. If you are not online, and online with appropriate messaging, you risk being" invisible" to Gen-X/Gen-Y future clients. Here is why: Baby boomers tend to ask friends for referrals and then act on the referrals. Gen-X/Gen-Y will ask for the same types of referrals from friends but will also do their own research on the Internet! Have you ever Googled yourself and your firm? I recommend that this "listening" exercise be done at least quarterly as best practice. Assessing your online presence can involve listening, monitoring your own and firm-wide messaging for consistency (and compliance). Now, another self-audit is essential: Do the language and value propositions resonate with your new, future clients? If not, you are at risk of relying on older, clients whose wealth and number are trending downward.

Enter social media marketing and how it can be used to create thought-leadership for you and your firm. Its the mash-up of "old skool" marketing but delivered via "new school" platforms. Personal/corporate branding can be accomplished through communicating consistent messages reflecting your firm's strengths and targeting toward the new value propositions of Gen-X/Gen-Y along with baby-boomers. Social media platforms like LinkedIn, Twitter, Facebook and others will lead you to engaging with future clients who are utilizing these sites to connect, learn and engage. Social media messaging can be targeted, niche-y and is much more effective (and much less costly) than other forms of marketing.

Next step is to take an honest, good look in the mirror and decide: Do I need a facelift?

?

Follow April Rudin on Twitter: www.twitter.com/TheRudinGroup

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Friday, June 1, 2012

VoIP Phone Service: Delivers Unified Communication | Ippbxthai.com

In the early years of 21st century, the VoIP phone service has brought in a revolution of all sorts in the communication industry. The advanced IP telephony Services deliver unified communication over the internet. The media-rich collaborative applications wherein voice, video, data and images are sent simultaneously have unified communications to a significant extent. As a natural corollary, the Voice over IP service has gained in popularity among various business entities

The small and medium sized enterprises as well as individual users are considering the IP telephony solutions for their day-to-day communications. As a matter of fact, it can be said that they are moving ahead on the footsteps of the large Business or corporate houses. The business entities are opting for the VoIP services to improve their internal operations while, the individual users are happy with the significant reductions in the phone bills.

The advanced VoIP phone services allow the users to enjoy long distance and international calls at significantly lower rates. This is possible due to the internet that allows the unified communication over the packet switching technique.

The best part of VoIP phone service is that the subscribers can use the pre-existing fixed line phones as well as mobiles.

As of now, the situation is such that the VoIP service is on the edge of replacing traditional PSTN system to a large extent, if not fully. The internet VoIP phone service provide ease and convenience of talking over the internet. As a matter of fact, such services are turning to be appropriate for frequent travelers and busy professionals as well. It keeps the employees or users connected with the business or others, even when the employee or the user is on the road or at home.

Some other task that such a phone service can facilitate over the traditional PSTN phone services are:

1. The VoIP phones are location friendly that can be operated from anywhere, as only internet connection is required to connect with others.

2. Incoming phone calls are automatically routed over internet, regardless of where the users are located at specific points in time. Therefore, frequent travels or others can enjoy calling at cheaper rates, even when they are on a trip.

3. The users can enjoy unlimited long distance and international calls with VoIP phone services at relatively lower rates. As a matter of fact, one can save up to half the cost of PSTN monthly bills.

4. Unlike PSTN services, the VoIP phones can be used to avail new and value added services that are available over the internet such as video conversation; messaging or data file exchange in parallel with the conversation, audio conferencing and passing of information.

VoIP services follow the IP process, wherein voice calls or images are routed over a broadband speed internet. As a matter of fact, there are three ways of transmitting the calls namely ? IP phones, PC to PC communication and Analog Telephone Adaptor or ATAs. The users could opt for anyone to facilitate unified communication over the diverse destinations and without much trouble.

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Insight: Butler's journey from trusted servant to accused Judas

VATICAN CITY (Reuters) - Just after dawn on Wednesday, May 23, Paolo Gabriele said goodbye to his wife, passed by the bedrooms of his three children and left to start another day in the service of the man Roman Catholics believe is the vicar of Christ on Earth.

By the end of the day, Pope Benedict's butler would be branded a traitor and some, including an Italian cardinal, would compare him to the most famous betrayer in history - Judas Iscariot, the man who turned Jesus over to the Romans.

Dark haired and handsome, Gabriele, 46, left his simple home on the third floor of a 1930s Vatican apartment block named after the 7th century monk Saint Egidio.

With the St Ann's Gate entrance, guarded by Swiss Guard in blue berets, to his back, he passed the Holy See's central post office on Via Del Belvedere, turned left to climb a stone stairway named after Pope Pius X, and walked up a flight of covered steps to enter the small Renaissance-era Courtyard of Sixtus V.

Here he used a key held by fewer than 10 people to enter an elevator that leads directly to the pope's private apartment on the third and top floor of the Apostolic Palace in the world's smallest state. Even cardinals can't use it.

Gabriele, said by those who know him to be a timid, reserved and shy man, is now at the centre of the worst crisis in Pope Benedict's pontificate.

His face has appeared on the front pages of newspapers all over the world, accused of being the source of leaked documents alleging serious Vatican corruption and cronyism in a scandal that has shaken the very centre of the Church.

To some - even if he is found guilty - he is an idealist who wanted to root out corruption in the Vatican and was helped by outside accomplices. To others, he is merely a pawn in a much bigger power struggle among cardinals inside the Vatican walls.

"I know Paolo and I don't think he is capable of doing something like this by himself," a person who spoke on the condition of anonymity told Reuters.

"It is clearly a betrayal of the pope's trust but I don't think he could have acted alone," that person said.

That Wednesday morning when Gabriele, dressed in a dark suit and white shirt, entered the private papal apartment, he walked down a corridor past the pope's modern private chapel, with its stained glass ceiling and white leather kneelers.

Even as he was serving the pope his breakfast, after the pontiff had said mass with other members of the "papal family" that morning, Gabriele knew he was a suspect in an investigation into leaks that had begun in January.

"He was questioned earlier but the decisive elements that permitted the arrest surfaced later," a Vatican official said, adding that one of the pope's two private secretaries, Monsignor Georg Ganswein, had confronted Gabriele with his suspicions.

LAST RIDE IN THE POPEMOBILE

At precisely 10:30 that sunny Wednesday morning, Benedict rode in his white popemobile through the Arch of the Bells into St Peter's Square to start his weekly audience. Gabriele was in his usual place, to the right of the driver, and his stony face showed no emotion.

It was the last ride he would take in the iconic vehicle that carries the man world diplomacy recognizes not only as leader of 1.2 billion Roman Catholics but as "The Sovereign of the State of Vatican City."

That afternoon, agents led by Domenico Giani, 49, the shaven-headed Vatican police chief who is known by the diminutive "Mimmo" to his friends, rang the buzzer on the Gabriele family apartment and entered.

Giani was formerly a member of the Italian secret service.

"It's not a fancy place - four rooms, a bath and a kitchen, if I remember correctly," someone who has been inside told Reuters.

Inside, they found what the Vatican newspaper L'Osservatore Romano - which waited nearly a week before writing about the arrest - called "a large number of confidential documents" belonging to the pope.

"A sense of tension, disorientation, stupor and sadness fell over the whole place like a thick fog after news of Paolo's arrest spread," said one Vatican worker describing the mood of employees from priests to postmen in the following days.

Because the Vatican does not have a jail, Gabriele is being held in a simple "safe room" with a bed and small table in the Vatican police station.

But the question on many people's minds and lips, including Gabriele's friends, was "Why? What is the motive?"

If he is guilty, why would Paoletto (little Paul, as he known), a devout Catholic and devoted father, betray the man whose official titles include "Successor of the Prince of the Apostles" and "Servant of the Servants of God"?

People who know Gabriele, now called "the defendant" in Vatican statements, exclude money as a motive.

They say the butler, who still attends Mass each day in the police station, would not have been able to spend it anywhere without raising suspicion; unless he left his job and probably even Italy.

And why, at 46 with three small children, would he leave a simple but comfortable life in the Vatican? While Vatican employees do not receive large salaries, they do enjoy benefits such as low rent, no income tax and cheap food and petrol at the commissaries of the 108-acre city state.

NO CHECKBOOK JOURNALISM, SAYS AUTHOR

Gianluigi Nuzzi, the Italian journalist who revealed many of the documents alleging corruption in the Vatican and internal conflict over the role of the Vatican bank, declines to reveal his sources but insists he did not pay anyone.

Nuzzi, a respected journalist with a good track record whose book "His Holiness: The Secret Papers of Benedict XVI," contains some of the allegations, says his sources were simple, devout people "genuinely concerned about the Catholic Church" who wanted to expose corruption.

People who know Gabriele, who started out as a humble cleaning person in the Vatican, said there was no indication either that he could have been blackmailed over his private life to force him to leak the documents.

Apart from Gabriele, the few other people who could go directly into the papal apartments via the reserved private elevator at the base of the Sixtus V courtyard include the pope's two priest secretaries, Ganswein and Maltese Monsignor Alfred Xuereb, and four consecrated women of "Memores Domini".

Memores Domini is an association of lay women, similar to nuns, who take vows of poverty, chastity and obedience within the Catholic organization Communion and Liberation. Their names are Carmela, Loredana, Cristiana and Rossella.

The fact that Gabriele was part of a tightly knit group known as "the papal family" explains the sadness and bitterness in the pope's words when he first spoke about the crisis in public on Wednesday, exactly one week after the butler's arrest.

"Our life and our Christian path are often marked by difficulties, incomprehension and suffering," he said, adding that all people must persevere in the face of "conflicts in human relations, often within one's own family".

While the pope's secretaries and the four women who help him run the simple household live in the papal residence, Gabriele stayed in his own apartment nearby with his family.

"He lived in the Vatican but not in the papal apartment," one Church official who knows Gabriele told Reuters. "He could have met with anyone in the Vatican or outside the Vatican".

In an interview with Reuters, Nuzzi would not say if any of the documents he had received came from Gabriele.

His book contains a treasure trove of private Vatican correspondence, including documents alleging cronyism and corruption in contracts with Italian companies, conspiracies among cardinals and clashes over management at the Vatican's own bank, the Institute for Works of Religion, or IOR.

He said the book, which hit the stands last week and is already sold out in Rome, is based on confidential conversations with more than 10 Vatican whistleblowers.

LOOKING FOR THE CROWS

The Vatican has not contested the authenticity of the documents but says their leak was part of a "brutal" personal attack on the pope and their publication "a criminal act".

The Italian media have dubbed the people who have leaked the documents "Corvi" (crows), a pejorative Italian term for an informant.

"They are not crows, they are doves who wanted to shed light, clean their air," Nuzzi told Reuters. "If the image of the Vatican that emerges is negative, it is not my fault, it is because of what is written in the documents."

The leaks began in January when an investigative television show hosted by Nuzzi broadcast private letters to Secretary of State Cardinal Tarcisio Bertone and the pope from Archbishop Carlo Maria Vigano, former deputy governor of the Vatican City, who has been moved to Washington as the Vatican's ambassador.

The letters showed Vigano was transferred after he exposed what he said was a web of corruption and cronyism linked to the awarding of contracts at inflated prices to Italian contractors.

Bertone responded by removing Vigano from his position three years before the end of his tenure and sending him to the United States, despite his strong resistance.

Bertone, whose job is to keep the Vatican's central administration, or Curia, running smoothly for the pope, now looks weakened after the leaks scandal and other failures.

They include the abrupt departure last week of the Vatican bank's Italian chief Ettore Gotti Tedeschi - who was recruited by Bertone from Spanish bank Santander - after a no-confidence vote by its board.

At his position in the papal apartments, Gabriele was in a prime position to see at least some of the disarray and tension in the Curia. But it remains to be seen whether he really was a pawn used by others to undermine Bertone, as some sources say.

"This is a strategy of tension, an orgy of vendettas and pre-emptive vendettas that has now spun out of the control of those who thought they could orchestrate it," said Alberto Melloni, a prominent Italian Church historian.

After his arrest Gabriele called an old school friend and devout catholic, Carlo Fusco, and asked him to be his defense lawyer. Fusco, a civil advocate, called in criminal lawyer Cristiana Arru to help with Gabriele's defense.

Gabriele's fate is now in the hands of Piero Antonio Bonnet, the Vatican's public prosecutor.

He will decide if the man who once was trusted with the keys to the papal elevator should stand trial for aggravated theft, or even worse, disclosing the documents of a head of state or breaking a special pontifical law protecting papal confidentiality.

The pope has tried to end talk of conflict under his roof.

Breaking his silence on the scandal on Wednesday, he expressed full confidence in his staff, including those who he said work "in silence" to help him carry out his ministry.

But that group no longer includes Gabriele, who only a few days ago was one of the closest men to Pope Benedict but now sits in a lonely room in the Vatican awaiting his fate.

(Additional reporting by Silvia Aloisi, Paolo Biondi, Tom Heneghan and James Mackenzie, editing by Barry Moody and Ralph Boulton)

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Judge Judy dishes out advice on her new website

FILE - In this April 17, 2012 file photo, Judge Judy Sheindlin attends the Vanity Fair Tribeca Film Festival party at the State Supreme Courthouse in New York. TV's "Judge Judy" has launched a website, www.whatwouldjudysay.com, to foster discussion about life experiences. (AP Photo/Evan Agostini, file )

FILE - In this April 17, 2012 file photo, Judge Judy Sheindlin attends the Vanity Fair Tribeca Film Festival party at the State Supreme Courthouse in New York. TV's "Judge Judy" has launched a website, www.whatwouldjudysay.com, to foster discussion about life experiences. (AP Photo/Evan Agostini, file )

FILE - In this April 17, 2012 file photo, Judge Judy Sheindlin attends the Vanity Fair Tribeca Film Festival party at the State Supreme Courthouse in New York. TV's "Judge Judy" has launched a website, www.whatwouldjudysay.com, to foster discussion about life experiences. (AP Photo/Evan Agostini, file )

(AP) ? Judge Judy is doing more than holding court on TV. She's now dishing out advice online.

Judy Sheindlin said the goal of her new website is to share her ideas about life, create a forum to discuss a variety of issues and to "have a little fun."

She'll have her say on topics including romance, pre-nuptial agreements and child-rearing. On the matter of "roommates with benefits," for instance, Sheindlin advises, "Joint nothing; separate everything!"

She's also inviting people to submit their own stories, some of which will be posted on the site.

"Judge Judy," her top-rated daytime syndicated show, is in its 16th year.

___

Online:

http://www.whatwouldjudysay.com

Associated Press

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